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SLC7A11 Antibody#43437

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Product Detail

Product NameSLC7A11 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntigen affinity purification.

ApplicationsWB IHC

Species ReactivityHu

SpecificityThe antibody detects endogenous levels of total SLC7A11 protein.

Immunogen DescSynthetic peptide of human SLC7A11

Target NameSLC7A11

ConjugateUnconjugated

Other NamesxCT; CCBR1

Accession NoSwiss-Prot#: Q9UPY5
Gene ID: 23657

Uniprot Q9UPY5

Gene ID 23657;

Calculated MW55kd. 35kd

Concentration2.3mg/ml

FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

StorageStore at -20˚C

Application Details
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:20-1:100
Immunohistochemical analysis of paraffin-embedded Human brain tissue using #43437 at dilution 1/35.
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #43437 at dilution 1/35.
Western blot analysis of SLC7A11 expression in mouse kidney (A), rat liver (B) whole cell lysates.

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

If you have published an article using product 43437, please notify us so that we can cite your literature.

et al,Pyroptotic macrophages induce disruption of glutamate metabolism in periodontal ligament stem cells contributing to their compromised osteogenic potential. In Cell Prolif on 2024 Oct by Li-Juan Sun, Hong-Lei Qu,et al..PMID:38803043 , (2024),
PMID: 38803043

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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