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ABCA1 Antibody#43463

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Product Detail

Product NameABCA1 Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntigen affinity purification.

ApplicationsIHC

Species ReactivityHu

SpecificityThe antibody detects endogenous levels of total ABCA1 protein.

Immunogen DescSynthetic peptide of human ABCA1

Target NameABCA1

ConjugateUnconjugated

Other NamesTGD; ABC1; CERP; ABC-1; HDLDT1

Accession NoSwiss-Prot#: O95477
Gene ID: 19

Uniprot O95477

Gene ID 19;

Concentration2mg/ml

FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

StorageStore at -20˚C

Application Details

Immunohistochemistry: 1:20-1:100

Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using #43463 at dilution 1/35.
Immunohistochemical analysis of paraffin-embedded Human tonsil tissue using #43463 at dilution 1/35.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

If you have published an article using product 43463, please notify us so that we can cite your literature.

et al,Niacin-induced lysosomal free cholesterol efflux via LXRα-mediated signaling pathways in macrophages retards the progression of atherosclerosis , (2025),
PMID:

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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