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DDC Antibody#43658

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Product Detail

Product NameDDC Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntigen affinity purification

ApplicationsWB

Species ReactivityHu

SpecificityThe antibody detects endogenous levels of total DDC protein.

Immunogen Typepeptide

Immunogen DescSynthetic peptide of human DDC

Target NameDDC

ConjugateUnconjugated

Other NamesAADC

Accession NoSwiss-Prot#: P20711
NCBI Gene ID: 1644

Uniprot P20711

Gene ID 1644;

Calculated MW54kd

Concentration0.7mg/ml

FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

StorageStore at -20˚C

Application Details
Western blotting: 1:500-2000
Gel: 8%SDS-PAGE
Lysate: 40 μg, Lane 1-2: Human left kidney tissue and Human fetal liver tissue lysates,
Primary antibody:DDC antibody at dilution 1/800,
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,
Exposure time: 10 seconds
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

If you have published an article using product 43658, please notify us so that we can cite your literature.

et al,5-HT2A Receptor and 5-HT Degradation Play a Crucial Role in Atherosclerosis by Modulating Macrophage Foam Cell Formation, Vascular Endothelial Cell Inflammation, and Hepatic Steatosis. In J Atheroscler Thromb on 2021 Feb 2 by Yingying Ma, Xiurui Liang,et al..PMID: 33536397 , (2021),
PMID: 33536397
et al,The activation of 5-hydroxytryptamine degradation system in proximal renal tubular epithelial cells induced by renal ischemia-reperfusion injury , (2021),
PMID:

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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