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GANAB Antibody#43659

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Product Detail

Product NameGANAB Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntigen affinity purification

ApplicationsIHC

Species ReactivityHu

SpecificityThe antibody detects endogenous levels of total GANAB protein.

Immunogen Typepeptide

Immunogen DescSynthetic peptide of human GANAB

Target NameGANAB

ConjugateUnconjugated

Other NamesAPC11; Apc11p; HSPC214

Accession NoSwiss-Prot#: Q14697
NCBI Gene ID: 23193

Uniprot Q14697

Gene ID 23193;

Concentration0.4mg/ml

FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

StorageStore at -20˚C

Application Details

Immunohistochemistry: 1: 20-100
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using GANAB Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using GANAB Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200)
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

If you have published an article using product 43659, please notify us so that we can cite your literature.

et al,Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules , (2021),
PMID:

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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