Product Detail
Product NameIGF1R Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntigen affinity purification
ApplicationsIHC
Species ReactivityHu
SpecificityThe antibody detects endogenous levels of total IGF1R protein.
Immunogen Typepeptide
Immunogen DescSynthetic peptide of human IGF1R
Target NameIGF1R
ConjugateUnconjugated
Other NamesIGFR; CD221; IGFIR; JTK13
Accession NoSwiss-Prot#: P08069
NCBI Gene ID: 3480
Uniprot
P08069
Gene ID
3480;
Concentration0.8mg/ml
FormulationRabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
StorageStore at -20˚C
Application Details
Immunohistochemistry: 1: 20-100
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using IGF1R Antibody at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200)
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.?
If you have published an article using product 43735, please notify us so that we can cite your literature.
et al,Investigating Serum and Placental Levels of IGF-1 and IGF-1R in Preeclampsia Patients and Their Clinical Implications.
, (2025),
PMID:
40099233
The lead time is currently 1 week.
