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Location： Home > Mouse Monoclonal Antibodies > Protein FAM38A Antibody

Protein FAM38A Antibody#48073

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Product Detail

Product NameProtein FAM38A Antibody

Clone No.210

Host SpeciesMouse

ClonalityMonoclonal

PurificationProA affinity purified

ApplicationsWB, IHC, ICC

Species ReactivityHu, Ms

Immunogen DescRecombinant protein.

ConjugateUnconjugated

Other NamesDHS
Fam38a
Family with sequence similarity 38 member A
KIAA0233
Membrane protein induced by beta-amyloid treatment
Mib
PIEZ1_HUMAN
Piezo-type mechanosensitive ion channel component 1
PIEZO1
Protein FAM38A
Protein FAM38B
Protein PIEZO1

Accession NoSwiss-Prot#:Q92508

Uniprot Q92508

Gene ID 9780;

Calculated MW287 kDa

Concentration2 mg/mL

Formulation1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details

WB 1:500-1:2000；
IHC 1:200-1:600；
ICC 1:100；

Western blot analysis of FAM38A on MCF-7 cell lysates with Mouse anti-FAM38A antibody at 1/500 dilution.
Immunocytochemistry analysis of Hela cells with FAM38A at 1/100 dilution.
Immunocytochemistry analysis of A431 cells with FAM38A at 1/100 dilution.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue with FAM38A at 1/200 dilution.
Immunohistochemical analysis of paraffin-embedded rat brain tissue with FAM38A at 1/600 dilution.

Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.

If you have published an article using product 48073, please notify us so that we can cite your literature.

et al,Impaired AT2 to AT1 cell transition in PM2.5-induced mouse model of chronic obstructive pulmonary disease. In Respir Res on 2022 Mar 25 by Hongjiao Yu, Yingnan Lin,et al..PMID:35337337 , (2022),
PMID: 35337337

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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