Product Detail
Product NameAKR7A2 Antibody
Clone No.C10-D5
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, ICC, IHC
Species ReactivityHu, zebrafish
Immunogen Descpeptide
ConjugateUnconjugated
Other NamesAFAR antibody
AFAR1 antibody
AFB1 aldehyde reductase 1 antibody
AFB1 AR1 antibody
AFB1-AR 1 antibody
AFB1AR1 antibody
Aflatoxin aldehyde reductase antibody
Aflatoxin B1 aldehyde reductase member 2 antibody
Aflatoxin beta1 aldehyde reductase antibody
Aiar antibody
AKR7 antibody
Akr7a2 antibody
Aldo keto reductase family 7 antibody
Aldo keto reductase family 7 member A2 aflatoxin aldehyde reductase antibody
Aldo keto reductase family 7 member A2 antibody
Aldo keto reductase family 7, member A2 (aflatoxin aldehyde reductase) antibody
Aldoketoreductase 7 antibody
ARK72_HUMAN antibody
SSA reductase antibody
Succinic semialdehyde reductase antibody
Accession NoSwiss-Prot#:O43488
Uniprot
O43488
Gene ID
8574;
Calculated MW40 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
ICC: 1:200
Western blot analysis of AKR7A2 on human spermatozoa lysate using anti-AKR7A2 antibody at 1/1,000 dilution.
ICC staining AKR7A2 in HepG2 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Aflatoxin B1 aldehyde reductase member 2 is an enzyme that in humans is encoded by the AKR7A2 gene. It catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate and may have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). AKR7A2 has broad substrate specificity and NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2 can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro) and reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It may be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
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