Product Detail
Product NameCathepsin B Antibody
Clone No.J11-A11
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, ICC, IHC
Species ReactivityHu, zebrafish
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAmyloid precursor protein secretase antibody
APP secretase antibody
APPS antibody
CATB_HUMAN antibody
Cathepsin B heavy chain antibody
Cathepsin B1 antibody
CathepsinB antibody
CPSB antibody
CTSB antibody
cysteine protease antibody
OTTHUMP00000116009 antibody
OTTHUMP00000229510 antibody
OTTHUMP00000229511 antibody
OTTHUMP00000229512 antibody
OTTHUMP00000229514 antibody
OTTHUMP00000229515 antibody
OTTHUMP00000229516 antibody
Preprocathepsin B antibody
Accession NoSwiss-Prot#:P07858
Uniprot
P07858
Gene ID
1508;
Calculated MW38kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:5,000-1:10,000
ICC: 1:200-1:500
Western blot analysis of Cathepsin B on SW480 cell lysate using anti-Cathepsin B antibody at 1/5,000 dilution.
ICC staining Cathepsin B in HepG2 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. In humans, it is coded by the CTSB gene. A wide array of diseases results in elevated levels of cathepsin B, which causes numerous pathological processes including cell death, inflammation, and production of toxic peptides. Focusing on neurological diseases, cathepsin B gene knockout studies in an epileptic rodent model have shown cathepsin B causes a significant amount of the apoptotic cell death that occurs as a result of inducing epilepsy. Mutations in the CTSB gene have been linked to tropical pancreatitis, a form of chronic pancreatitis.
If you have published an article using product 48118, please notify us so that we can cite your literature.
et al,Coprophagy Prevention Decreases the Reproductive Performance and Granulosa Cell Apoptosis via Regulation of CTSB Gene in Rabbits. In Front Physiol
on 2022 Jul 18 by Guohua Song, Yadong Wang, et al..PMID:35923240
, (2022),
PMID:
35923240
Yes
