Product Detail
Product NameAcetyl CoA Carboxylase 1 (ACC1) Antibody
Clone No.2G3
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IP, IF
Species ReactivityHu
Immunogen Descpeptide
ConjugateUnconjugated
Other NamesACAC antibody ACACA antibody ACACA_HUMAN antibody ACACB antibody ACC alpha antibody ACC antibody ACC beta antibody ACC-alpha antibody ACC1 antibody ACC2 antibody ACCA antibody ACCB antibody Acetyl CoA carboxylase 1 antibody Acetyl CoA carboxylase 2 antibody Acetyl CoA carboxylase alpha antibody Acetyl CoA carboxylase beta antibody Acetyl Coenzyme A carboxylase alpha antibody Acetyl Coenzyme A carboxylase beta antibody Biotin carboxylase antibody COA1 antibody COA2 antibody HACC275 antibody OTTHUMP00000164069 antibody OTTHUMP00000164070 antibody OTTHUMP00000164076 antibody OTTHUMP00000240532 antibody
Accession NoSwiss-Prot#:Q13085
Uniprot
Q13085
Gene ID
31;
Calculated MW265 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein
Western blot analysis of ACCα expression in DU 145 (A) and Jurkat (B) whole cell lysates
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzymes short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus.
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