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Location： Home > Mouse Monoclonal Antibodies > CD11c / ITGAX Antibody

CD11c / ITGAX Antibody#48280

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Product Detail

Product NameCD11c / ITGAX Antibody

Clone No.3G1

Host SpeciesMouse

ClonalityMonoclonal

PurificationProA affinity purified

ApplicationsWB, IP, IF, IHC(P)

Species ReactivityHu, Ms, Rt

Immunogen Descpeptide

ConjugateUnconjugated

Other Names95 alpha chain antibody
95 antibody
CD 11c antibody
CD11 antigen like family member C antibody
CD11 antigen-like family member C antibody
CD11c antibody
CD11c antigen antibody
Complement component 3 receptor 4 subunit antibody
CR4 antibody
Integrin alpha X antibody
Integrin alpha X chain antibody
Integrin alpha-X antibody
Integrin aX antibody
Integrin subunit alpha X antibody
integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody
integrin, alpha X (complement component 3 receptor 4 subunit antibody
ITAX_HUMAN antibody
ITGAX antibody
LEU M5 alpha subunit antibody
Leu M5 antibody
Leukocyte adhesion glycoprotein p150 95 alpha chain antibody
Leukocyte adhesion glycoprotein p150 antibody
Leukocyte adhesion receptor p150 95 antibody
Leukocyte adhesion receptor p150 antibody
Leukocyte surface antigen p150 95 alpha subunit antibody
Leukocyte surface antigen p150 alpha subunit antibody
Myeloid membrane antigen alpha subunit antibody
p150 95 integrin alpha chain antibody
p150 antibody
p150/95 antibody
SLEB6 antibody

Accession NoSwiss-Prot#:P20702

Uniprot P20702

Gene ID 3687;

Calculated MW145kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at 4˚C

Application Details

WB: 1:100-1:1,0000
IHC: 1:50-500

IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)

Western blot analysis of Integrin αX expression in non-transfected 293T (A), human Integrin αX transfected 293T (B) and HL-60 (C) whole cell
Western blot analysis of Integrin αX expression in AML-193 whole cell lysate.

Integrin ?X (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with 2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin ?X/2 shares similar properties of the ?M/2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin ?X is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin ?X include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin ?X is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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