Product Detail
Product NameCitrate synthase Antibody
Clone No.1G1
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IP, IF, IHC(P)
Species ReactivityHu, Ms, Rt
Immunogen DescAn epitope mapping between amino acids 259-292 of citrate synthase of human origin.
ConjugateUnconjugated
Other NamesCISY_HUMAN antibody Citrate synthase antibody Citrate synthase, mitochondrial antibody citrate synthetase antibody Cs antibody EC 2.3.3 antibody EC 2.3.3.1 antibody
Accession NoSwiss-Prot#:O75390
Uniprot
O75390
Gene ID
1431;
Calculated MW52kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:100-1:1,000
IHC: 1:50-500
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
Western blot analysis of citrate synthase expression in non-transfected 293T (A), mouse citrate synthase transfected 293T (B) and K-562 (C) whole cell lysates.
Citrate synthase (CS) is a 466 amino acid mitochondrial matrix protein that functions as the first and rate-limiting enzyme of the tricarboxylic acid cycle. Essential in mitochondrial respiration and involved in the conversion of glucose to lipid, citrate synthase is found the great majority of cells that are capable of oxidative metabolism. The gene encoding citrate synthase maps to human chromosome 12q13.3, which is transcribed into two alternatively spliced variants designated CSa and CSb. Human chromosome 12 encodes over 1,100 genes, comprises approximately 4.5% of the human genome and is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.
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