Product Detail
Product NameFOXF2 Antibody
Clone No.3G1
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IP, IF
Species ReactivityHu, Ms
Immunogen DescRecombinant FOXF2 of human origin.
ConjugateUnconjugated
Other NamesFKH L6 antibody FKHL 6 antibody FKHL6 antibody Forkhead box F2 antibody Forkhead box protein F2 antibody Forkhead like 6 antibody Forkhead related activator 2 antibody Forkhead related protein FKHL6 antibody Forkhead related transcription factor 2 antibody Forkhead, Drosophila, homolog-like 6 antibody FOX F2 antibody FOXF 2 antibody FREAC 2 antibody FREAC2 antibody OTTHUMP00000017863 antibody
Accession NoSwiss-Prot#:Q12947
Uniprot
Q12947
Gene ID
2295;
Calculated MW40 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF 1:50-500
Western blot analysis of FOXF2 expression in HepG2 (A), HeLa (B), A549 (C) and THP-1 (D) nuclear extracts.
Immunofluorescence staining of paraformaldehyde-fixed HeLa cells showing nuclear localization.
The FOX family of transcription factors share a common DIUA binding domain termed a winged-helix or forkhead domain. Many FOX proteins play important roles in development, metabolism, cancer and aging. Development of the vertebrate gut is controlled by paracrine crosstalk between the endodermal epithelium and the associated splanchnic mesoderm. FOXF2 (forkhead box F2), also known as FKHL or FREAC2, is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. FOXF2 interacts with transcription factors TFIIB and TBP, and may be involved in regulating transcription in embryogenesis and pattern formation in multicellular organisms. FOXF2-deficient mice develop cleft palate and an abnormal tongue, which suggests that FOXF2 may be critical for palatogenesis.
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