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Location： Home > Mouse Monoclonal Antibodies > FOXM1 Antibody

FOXM1 Antibody#48295

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Product Detail

Product NameFOXM1 Antibody

Clone No.4G1

Host SpeciesMouse

ClonalityMonoclonal

PurificationProA affinity purified

ApplicationsWB, IP, IF

Species ReactivityHu, Ms, Rt

Immunogen Descpeptide

ConjugateUnconjugated

Other NamesFKHL16 antibody
Forkhead box M1 antibody
Forkhead box protein M1 antibody
forkhead like 16 antibody
Forkhead-related protein FKHL16 antibody
FOX M1 antibody
Foxm1 antibody
FOXM1_HUMAN antibody
FOXM1B antibody
Hepatocyte nuclear factor 3 forkhead homolog 11 antibody
HFH-11 antibody
HFH11 antibody
HNF-3/fork-head homolog 11 antibody
HNF3 antibody
INS1 antibody
M phase phosphoprotein 2 antibody
M-phase phosphoprotein 2 antibody
MPHOSPH2 antibody
MPM-2 reactive phosphoprotein 2 antibody
MPP2 antibody
PIG29 antibody
TGT3 antibody
Transcription factor Trident antibody
Trident antibody
WIN antibody
Winged-helix factor from INS-1 cells antibody
Winged-helix factor from INS1 cells antibody

Accession NoSwiss-Prot#:Q08050

Uniprot Q08050

Gene ID 2305;

Calculated MW83 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at 4˚C

Application Details

WB: 1:100-1:1,000


IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)

A.Western blot analysis of FOXM1 expression in EGF treated HeLa (A) and U-2 OS (B) whole cell lysates.
Western blot analysis of FOXM1 expression in CCRF-CEM whole cell lysate.

The Fox family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. FOXM1, also known as FKHL16, MPP2 or Trident, is primarily expressed in proliferating cells. The gene encoding human FOXM1 maps to chromosome 12p13. The transcription element that restricts FOXM1 expression to proliferating cells is located 300 bp upstream of the start codon. FOXM1 is most abundant in thymus, testis, small intestine and colon. Alternative splicing generates FOXM1A and FOXM1B isoforms that contain PEST regions involved in rapid protein degradation. A decrease in FOXM1 expression is associated with age-related defects in cellular proliferation. Conversely, an increase in FOXM1B expression in the livers of older transgenic mice restore hepatocyte DNA replication rates to the higher rate present in young livers. FOXM1B activates the transcription of cyclin B1, cyclin D1 and Cdc25B.

If you have published an article using product 48295, please notify us so that we can cite your literature.

et al,RNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1 , (2024),
PMID:

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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