Product Detail
Product NameKDR / VEGFR-2 Antibody
Clone No.1G1
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IP, IF, IHC(P)
Species ReactivityHu, Ms, Rt
Immunogen DescAmino acids 1158-1345 mapping at the C-terminus of the Flk-1 of mouse origin.
ConjugateUnconjugated
Other NamesCD309 antibody CD309 antigen antibody EC 2.7.10.1 antibody Fetal liver kinase 1 antibody FLK-1 antibody FLK1 antibody FLK1, mouse, homolog of antibody Kdr antibody Kinase insert domain receptor (a type III receptor tyrosine kinase) antibody Kinase insert domain receptor antibody KRD1 antibody Ly73 antibody Protein tyrosine kinase receptor FLK1 antibody Protein-tyrosine kinase receptor flk-1 antibody soluble VEGFR2 antibody Tyrosine kinase growth factor receptor antibody Vascular endothelial growth factor receptor 2 antibody VEGFR 2 antibody VEGFR antibody VEGFR-2 antibody VEGFR2 antibody VGFR2_HUMAN antibody
Accession NoSwiss-Prot#:P35968
Uniprot
P35968
Gene ID
3791;
Calculated MW200kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:100-1:1,000
IHC: 1:50-1:500
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
Western blot analysis of Flk-1 expression in non-transfected (A) and mouse Flk-1 transfected (B) 293T whole cell lysates.
Western blot analysis of Flk-1 expression in VEGF-treated HUV-EC-C whole cell lysate.
Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulinlike sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs). On the basis of structural similarity to Flt and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.
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