Product Detail
Product NameMDR1 Antibody
Clone No.1G6
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IP, IF
Species ReactivityHu, Ms, Rt
Immunogen DescMdr of hamster origin.
ConjugateUnconjugated
Other NamesABC20 antibody ABCB1 antibody ATP binding cassette, sub family B (MDR/TAP), member 1 antibody ATP-binding cassette sub-family B member 1 antibody CD243 antibody CLCS antibody Colchicin sensitivity antibody Doxorubicin resistance antibody GP170 antibody MDR1 antibody MDR1_HUMAN antibody Multidrug resistance 1 antibody Multidrug resistance protein 1 antibody P glycoprotein 1 antibody P gp antibody P-glycoprotein 1 antibody PGY1 antibody
Accession NoSwiss-Prot#:P08183
Uniprot
P08183
Gene ID
5243;
Calculated MW170 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:10-1:200
IHC: 1:10-1:200
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
Cells selected for resistance to a single cytotoxic drug may become cross-resistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). The MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance observed in human cancer cells following prolonged chemotherapy. The classic form of MDR is associated with an increase in the Mdr protein, but not all cases of MDR can be attributed to a rise in Mdr levels. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. In the human population, there are 15 polymorphisms in the Mdr-1 gene.
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