Product Detail
Product NameMKP-3 Antibody
Clone No.3G1
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IP, IF, IHC(P)
Species ReactivityHu, Ms, Rt
Immunogen Descpeptide
ConjugateUnconjugated
Other NamesDual specificity phosphatase 6 antibody Dual specificity phosphatase 6 isoform a antibody Dual specificity protein phosphatase 6 antibody Dual specificity protein phosphatase PYST1 antibody DUS6_HUMAN antibody DUSP 6 antibody DUSP 6a antibody Dusp6 antibody DUSP6a antibody HH19 antibody MAP kinase phosphatase 3 antibody Mitogen activated protein kinase phosphatase 3 antibody Mitogen-activated protein kinase phosphatase 3 antibody MKP 3 antibody MKP-3 antibody MKP3 antibody PYST 1 antibody PYST1 antibody Serine/threonine specific protein phosphatase antibody hide
Accession NoSwiss-Prot#:Q16828
Uniprot
Q16828
Gene ID
1848;
Calculated MW42 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:100-1:1,000
IHC: 1:50-1:500
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
Western blot analysis of MKP-3 expression in non-transfected (A) and human MKP-3 transfected (B) 293T whole cell lysates.
Immunoperoxidase staining of formalin fixed, paraffin-embedded human bronchus tissue showing cytoplasmic staining of respiratory epithelial cells.
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X, and MKP-4. Human MKP-3 maps to chromosome 12q21.33 and encodes a 381 amino acid protein that specifically inactivates members of the ERK family and is expressed in a variety of tissues with the highest levels in heart and pancreas.
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