Product Detail
Product NameTAL1 / SCL LS-C182473 Antibody
Clone No.4G1
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IP, IF
Species ReactivityHu, Ms, Rt
Immunogen Descpeptide
ConjugateUnconjugated
Other NamesbHLHa17 antibody Class A basic helix-loop-helix protein 17 antibody OTTHUMP00000009563 antibody OTTHUMP00000009564 antibody SCL antibody STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR antibody Stem cell protein antibody T cell acute lymphocytic leukemia 1 antibody T cell acute lymphocytic leukemia 1 protein antibody T cell acute lymphocytic leukemia 1 protein antibody T cell leukemia/lymphoma 5 protein antibody T-cell acute lymphocytic leukemia protein 1 antibody T-cell leukemia/lymphoma protein 5 antibody Tal 1 antibody Tal 1 product antibody TAL 1 protein antibody TAL-1 antibody tal1 antibody TAL1_HUMAN antibody TCL 5 antibody TCL5 antibody
Accession NoSwiss-Prot#:P17542
Uniprot
P17542
Gene ID
6886;
Calculated MW42kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
Western blot analysis of TAL1 expression in non-transfected (A) and human TAL1 transfected (B) 293T whole cell lysates and CCRF-CEM (C), Jurkat (D) and K-562 (E) nuclear extracts.
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic coexpression of TAL1 and the catalytic subunit of casein kinase IIα, a serine/ threonine protein kinase known to modulate the activity of other βHLH transcription factors.
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