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TNFR1 Antibody#48344

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Product Detail

Product NameTNFR1 Antibody

Clone No.2G2

Host SpeciesMouse

ClonalityMonoclonal

PurificationImmunogen affinity purified

ApplicationsWB, IP, IF, IHC(P)

Species ReactivityHu, Ms, Rt

Immunogen DescAmino acids 30-301 mapping within the extracellular domain of TNF-R1 of human origin.

ConjugateUnconjugated

Other NamesCD120a antibody
FPF antibody
MGC19588 antibody
p55 antibody
p55-R antibody
p60 antibody
TBP1 antibody
TBPI antibody
TNF R antibody
TNF R55 antibody
TNF-R1 antibody
TNF-RI antibody
TNFAR antibody
TNFR-I antibody
TNFR1 antibody
TNFR55 antibody
TNFR60 antibody
TNFRI antibody
TNFRSF1a antibody
TNR1A_HUMAN antibody
Tumor necrosis factor receptor 1 antibody
Tumor necrosis factor receptor superfamily, member 1A antibody
Tumor necrosis factor receptor type 1 antibody
Tumor necrosis factor receptor type I antibody
Tumor necrosis factor-binding protein 1 antibody

Accession NoSwiss-Prot#:P19438

Uniprot P19438

Gene ID 7132;

Calculated MW55 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at 4˚C

Application Details

WB: 1:100-1:1,000
IHC: 1:50-1:500

IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)

Western blot analysis of TNF-R1 expression in MCF7 (A), HeLa (B) and U-937 (C) whole cell lysates.
Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors. These receptors, designated TNF-R1 and TNF-R2 are expressed on most cell types. The majority of TNF functions are primarily mediated through TNF-R1, while signaling through TNF-R2 occurs less extensively and is confined to cells of the immune system. Both of these proteins belong to the growing TNF and nerve growth factor (NGF) receptor superfamily, which includes FAS, CD30, CD27 and CD40. The members of this superfamily are type I membrane proteins that share sequence homology confined to the extracellular region. TNF-R1 shares a motif coined the death domain with FAS and three structurally unrelated signaling proteins, TRADD, FADD and RIP. This death domain is required for transduction of the apoptotic signal.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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