Product Detail
Product NameXAF1 Antibody
Clone No.2G1
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IP, IF
Species ReactivityHu
Immunogen DescAmino acids 1-225 mapping at the N-terminus of XAF1 of human origin.
ConjugateUnconjugated
Other NamesBIRC 4 binding protein antibody BIRC4 binding protein antibody BIRC4-binding protein antibody BIRC4BP antibody HSXIAPAF 1 antibody HSXIAPAF1 antibody XAF 1 antibody XAF1 antibody XAF1_HUMAN antibody XIAP associated factor 1 antibody XIAP-associated factor 1 antibody XIAPAF1 antibody
Accession NoSwiss-Prot#:Q6GPH4
Uniprot
Q6GPH4
Gene ID
54739;
Calculated MW35 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:100-1:1,000
IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
Western blot analysis of XAF1 expression in non-transfected (A) and human XAF1 transfected (B) 293T whole cell lysates.
X-linked inhibitor of apoptosis protein (XIAP)-associated factor 1 (XAF1) is azinc finger protein that blocks the anti-apoptotic activity of XIAP. XIAP is amember of the family of intrinsic inhibitors of apoptosis proteins (IAPs), whichsuppress apoptosis through the inhibition of caspases. In the presence ofXAF1, XIAP protein redistributes from the cytosol to the nucleus. XAF1 transcripts(3.9-, 4.5-, 6.0- and 7.0-kb) are present at high levels in heart and ovary.Low expression of XAF1 mRNA is an indicator for certain cancers (WM164melanoma, WM35 melanoma, U937 pro-monocytic leukemia and HT1080fibrosarcoma), suggesting that low levels of XAF1 transcript may enhancecancer cell-survival through the relative increase in XIAP anti-apoptotic function.IFN-α and IFN-β activate the human XAF1 gene, which maps to chromosome17p13.1.
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