Product Detail
Product NameCELF1 Antibody
Clone No.7A1
Host SpeciesMouse
ClonalityMonoclonal
PurificationProtein affinity purified
ApplicationsIHC,WB
Species ReactivityHu
Immunogen DescRecombinant protein within human CELF1 aa 1-180.
ConjugateUnconjugated
Other Names50 kDa Nuclear polyadenylated RNA binding protein antibody
50 kDa nuclear polyadenylated RNA-binding protein antibody
Bruno like 2 antibody
bruno like protein 2 antibody
Bruno-like protein 2 antibody
BRUNOL 2 antibody
BRUNOL2 antibody
CELF 1 antibody
CELF-1 antibody
celf1 antibody
CELF1 CUGBP, Elav like family member 1 antibody
CELF1_HUMAN antibody
CUG BP and ETR 3 like factor 1 antibody
CUG BP antibody
CUG BP1 antibody
CUG RNA binding protein antibody
CUG triplet repeat RNA binding protein 1 antibody
CUG triplet repeat RNA-binding protein 1 antibody
CUG-BP antibody
CUG-BP- and ETR-3-like factor 1 antibody
CUG-BP1 antibody
CUGBP 1 antibody
CUGBP and ETR3 like factor 1 antibody
CUGBP antibody
CUGBP Elav like family member 1 antibody
CUGBP Elav-like family member 1 antibody
CUGBP1 antibody
Cytidine uridine guanosine binding protein 1 antibody
Deadenylation factor CUG BP antibody
Deadenylation factor CUG-BP antibody
Deadenylation factor CUGBP antibody
EDEN BP antibody
EDEN BP homolog antibody
EDEN-BP antibody
EDEN-BP homolog antibody
embryo deadenylation element binding protein antibody
embryo deadenylation element binding protein homolog antibody
Embryo deadenylation element-binding protein homolog antibody
hNab 50 antibody
hNab50 antibody
NAB 50 antibody
NAB50 antibody
NAPOR antibody
Nuclear polyadenylated RNA binding protein 50 kD antibody
Nuclear polyadenylated RNA binding protein antibody
RNA binding protein BRUNOL 2 antibody
RNA binding protein BRUNOL2 antibody
RNA-binding protein BRUNOL-2 antibody
Accession NoSwiss-Prot#:Q92879
Uniprot
Q92879
Gene ID
10658;
Calculated MW52 kDa
Formulation1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
IHC: 1:50-1:200
Western blot analysis of CELF1 on Daudi cell lysate using anti-CELF1 antibody at 1/5,000 dilution.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CELF1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-CELF1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CELF1 antibody. Counter stained with hematoxylin.
Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3'-untranslated region of the myotonin protein kinase gene (DMPK). CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5' region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawl.
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