Product Detail
Product NameTSH Antibody
Clone No.AH21-10
Host SpeciesMouse
ClonalityMonoclonal
ApplicationsWB, IHC, ICC
Species ReactivityHu, Ms
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCG ALPHA antibody
CGA antibody
Chorionic gonadotropin alpha polypeptide antibody
FSHA antibody
Glycoprotein hormones alpha polypeptide antibody
GPHA1 antibody
Thyroid stimulating hormone beta subunit antibody
Thyrotropin beta subunit antibody
TSH beta antibody
TSHA antibody
TSHB antibody
Accession NoSwiss-Prot#:P01215
Uniprot
P01215
Gene ID
1081;
Calculated MW42 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.23% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded mouse placenta tissue using anti-TSH antibody. Counter stained with hematoxylin.
ICC staining TSH in HepG2 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining TSH in JAR cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Various hormones are secreted from the anterior pituitary during development and growth, including thyroid-stimulating hormone (TSH, also known as thyrotropin), follicle-stimulating hormone (FSH) and leutinizing hormone (LH). TSH, FSH, and LH are heterodimers formed from a common α chain and a unique β chain. TSH is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSHβ is regulated by thyroid hormone (T3) and various retinoid compounds. TSHβ binds to the thyroid-stimulating hormone receptor (TSHR), which plays a major role in regulating thyroid function. TSHR is thought to exist in multiple glycosylation states. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation.
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