Product Detail
Product NameFBXL10 Antibody
Clone No.6G-11
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other Names[Histone-H3]-lysine-36 demethylase 1B antibody
CXXC-type zinc finger protein 2 antibody
CXXC2 antibody
F box and leucine rich repeat protein 10 antibody
F box protein FBL10 antibody
F-box and leucine-rich repeat protein 10 antibody
F-box protein FBL10 antibody
F-box/LRR-repeat protein 10 antibody
Fbl10 antibody
FBXL10 antibody
JEMMA (Jumonji domain EMSY interactor methyltransferase motif) protein antibody
JHDM1B antibody
JmjC domain-containing histone demethylation protein 1B antibody
Jumonji C domain containing histone demethylase 1B antibody
Jumonji domain-containing EMSY-interactor methyltransferase motif protein antibody
kdm2b antibody
KDM2B_HUMAN antibody
Lysine (K) specific demethylase 2B antibody
Lysine-specific demethylase 2B antibody
PCCX2 antibody
Protein containing CXXC domain 2 antibody
Protein JEMMA antibody
Protein-containing CXXC domain 2 antibody
Accession NoSwiss-Prot#:Q8NHM5
Uniprot
Q8NHM5
Gene ID
84678;
Calculated MW152 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
FC: 1:50-1:200
Western blot analysis of FBXL10 on human FBXL10 recombinant protein using anti-FBXL10 antibody at 1/1,000 dilution.
Western blot analysis of FBXL10 on HEK293 (1) and FBXL10-hIgGFc transfected HEK293 (2) cell lysate using anti-FBXL10 antibody at 1/1,000 dilution.
Western blot analysis of FBXL10 on A549 cell lysate using anti-FBXL10 antibody at 1/1,000 dilution.
Flow cytometric analysis of Hela cells with FBXL10 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
FBXL10 (F-box and leucine-rich repeat protein 10), also known as Fbl10, CXXC2 (CXXC-type zinc finger protein 2), PCCX2, KDM2B, JEMMA (jumonji domain, EMSY-interactor, methyltransferase motif protein) or JHDM1B (jumonji C domain-containing histone demethylase 1B), is a nuclear protein that contains one F-box domain, a CXXC-type zinc finger, one JMJC domain, four leucine-rich repeats and one PHD-type zinc finger. FBXL10 belongs to the Fbls class of F-box proteins that contain leucine-rich repeats in addition to their F-box motif. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. In addition to its role in substrate recognition as a component of the E3 complex, FBXL10 functions as a dimethylation-specific demethylase, binding iron as a cofactor and demethylating lysine-36 of Histone H3. This suggests that FBXL10 plays a central role in the histone code.
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