Product Detail
Product NameMuRF1 Antibody
Clone No.B8-E1
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsICC, IHC, FC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesE3 ubiquitin-protein ligase TRIM63 antibody
FLJ32380 antibody
IRF antibody
Iris RING finger protein antibody
MURF 1 antibody
MURF-1 antibody
MuRF1 antibody
MURF2 antibody
Muscle specific ring finger protein 1 antibody
Muscle specific ring finger protein 2 antibody
Muscle-specific RING finger protein 1 antibody
OTTHUMP00000008701 antibody
RING finger protein 28 antibody
RNF 28 antibody
RNF28 antibody
SMRZ antibody
Striated muscle RING zinc finger protein antibody
TRI63_HUMAN antibody
TRIM 63 antibody
Trim63 antibody
Tripartite motif containing 63 antibody
tripartite motif containing 63, E3 ubiquitin protein ligase antibody
Tripartite motif containing protein 63 antibody
Tripartite motif-containing protein 63 antibody
Ubiquitin ligase TRIM63 antibody
Accession NoSwiss-Prot#:Q969Q1
Uniprot
Q969Q1
Gene ID
84676;
Calculated MW40 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
IHC: 1:50-1:200
ICC: 1:50-1:200
FC: 1:50-1:100
Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using anti-MuRF1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded huamn muscle tissues? using anti-MuRF1 antibody. Counter stained with hematoxylin.
ICC staining MuRF1(green) and Actin filaments?(red)?in?Hela?cells.?The?nuclear?counter?stain?is?DAPI?(blue).?Cells?were?fixed?in?paraformaldehyde,?permeabilised? with?0.25%?Triton?X100/PBS.
Flow cytometric analysis of Hela cells with MuRF1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
Muscle specific RING finger protein (MuRF1) is a sarcomere-associated protein that is upregulated by conditions that provoke atrophy. Pharmacological or genetic inhibition of the IKKbeta/NF-kappaB/MuRF1 pathway reverses muscle atrophy, which presents MuRF as a target for clinical intervention. MuRF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy. MuRF1 directly associates with Titin kinase and influences microtubule-dependent signaling pathways in striated muscle and iris. MuRF1 upregulation is an indicator for skeletal muscle atrophy mechanisms that utilize ubiquitin-dependent proteolysis. MuRF1 transcript levels are high in situations where there is an overabundance of reactive oxygen species, such as cancer, AIDS and sepsis.
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