Product Detail
Product NameDHX58 Antibody
Clone No.A3-A6
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesD11LGP2 antibody
D11lgp2e antibody
DEXH (Asp Glu X His) box polypeptide 58 antibody
DEXH box polypeptide 58 antibody
DHX 58 antibody
DHX58 antibody
DHX58_HUMAN antibody
LGP 2 antibody
LGP2 antibody
Ortholog of mouse D11lgp2 antibody
Probable ATP dependent helicase LGP2 antibody
Probable ATP dependent RNA helicase DHX58 antibody
Probable ATP-dependent helicase LGP2 antibody
Probable ATP-dependent RNA helicase DHX58 antibody
Protein D11Lgp2 homolog antibody
RIG-I-like receptor LGP2 antibody
RLR antibody
RNA helicase LGP2 antibody
Accession NoSwiss-Prot#:Q96C10
Uniprot
Q96C10
Gene ID
79132;
Calculated MW77 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
FC: 1:50-1:200
Western blot analysis of DHX58 on human DHX58 recombinant protein using anti-DHX58 antibody at 1/1,000 dilution.
Western blot analysis of DHX58 on HEK293 (1) and DHX58-hIgGFc transfected HEK293 (2) cell lysate using anti-DHX58 antibody at 1/1,000 dilution.
Flow cytometric analysis of Hela cells with DHX58 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
Helicases are enzymes that catalyze the separation of double stranded DNA or RNA by utilizing ATP. LGP2, also known as probable ATP-dependent RNA helicase DHX58, is a 678 amino acid protein belonging to the helicase family. LGP2 acts as a negative regulator of host innate immune defense against viruses by binding dsRNA produced during viral replication. The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in host defenses against hepatitis C virus (HCV). By preventing RIG-I multimerization, LGP2 negatively regulates RIG-I-mediated signaling. Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and one helicase C-terminal domain.
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