Product Detail
Product NameTHAP1 Antibody
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, ICC, FC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other Names4833431A01Rik antibody
DYT6 antibody
FLJ10477 antibody
MGC33014 antibody
Nuclear proapoptotic factor antibody
THAP 1 antibody
THAP domain containing 1 antibody
THAP domain containing apoptosis associated protein 1 antibody
THAP domain containing protein 1 antibody
THAP domain protein 1 antibody
THAP domain-containing protein 1 antibody
Thap1 antibody
THAP1_HUMAN antibody
Accession NoSwiss-Prot#:Q9NVV9
Uniprot
Q9NVV9
Gene ID
55145;
Calculated MW25 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
ICC: 1:50-1:200
FC: 1:50-1:200
Western blot analysis of THAP1 on human THAP1 recombinant protein using anti-THAP1 antibody at 1/1,000 dilution.
Western blot analysis of THAP1 on HEK293 (1) and THAP1-hIgGFc transfected HEK293 (2) cell lysate using anti-THAP1 antibody at 1/1,000 dilution.
ICC staining THAP1 (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of Jurkat cells with THAP1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).
THAP1 (THAP domain containing, apoptosis associated protein 1) is a 213 amino acid protein that localizes to the nucleoplasm and contains one THAP-type zinc finger, a conserved DNA-binding domain. Interacting with PAR4, THAP1 functions as a pro-apoptotic protein that acts in a zinc-dependent manner and enhances the likelihood of both TNF- and serum withdrawal-induced apoptosis, possibly playing a role in promyelocytic leukemia. The gene encoding THAP1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.
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