Product Detail
Product NameANAPC11 Antibody
Clone No.H6-F1
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesANAPC 11 antibody
ANAPC11 antibody
Anaphase promoting complex subunit 11 (yeast APC11 homolog) antibody
Anaphase promoting complex subunit 11 antibody
Anaphase promoting complex subunit 11 homolog (yeast) antibody
Anaphase promoting complex subunit 11 homolog antibody
Anaphase-promoting complex subunit 11 antibody Apc 11 antibody
Apc 11p antibody
APC11 anaphase promoting complex subunit 11 homolog (yeast) antibody
APC11 anaphase promoting complex subunit 11 homolog antibody
APC11 antibody APC11_HUMAN antibody
Apc11p antibody Cyclosome subunit 11 antibody
Hepatocellular carcinoma associated RING finger protein antibody
Hepatocellular carcinoma-associated RING finger protein antibody
HSPC 214 antibody
HSPC214 antibody MGC882 antibody
Yeast APC 11 homolog antibody
Yeast APC11 homolog antibody
Accession NoSwiss-Prot#:Q9NYG5
Uniprot
Q9NYG5
Gene ID
51529;
Calculated MW10 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1,000
FC: 1:50-1:100
Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC's cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC; thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.
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