Product Detail
Product NameWHSC2 Antibody
Clone No.H8-B11
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, ICC, IHC, FC
Species ReactivityHu, Rt
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesFLJ10442 antibody
FLJ25112 antibody
Negative elongation factor A antibody
Negative elongation factor polypeptide A antibody
NELF A antibody
NELF-A antibody
NELFA antibody
NELFA_HUMAN antibody
P/OKcl.15 antibody
P/OKcl15 antibody
WHSC 2 antibody
Whsc2 antibody
Wolf Hirschhorn syndrome candidate 2 antibody
Wolf Hirschhorn syndrome candidate 2 protein antibody
Wolf-Hirschhorn syndrome candidate 2 protein antibody
Accession NoSwiss-Prot#:Q9H3P2
Uniprot
Q9H3P2
Gene ID
7469;
Calculated MW57 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:2,000
IHC: 1:100-1:200
ICC: 1:50-1:200
FC: 1:100-1:200
NELF-A, for negative elongation factor A, is a protein factor required for DRB-sensitive transcription. NELF-A is one of the five components of the multisubunit NELF complex that cooperates with DSIF to repress RNA polymerase II elongation. Control of transcription elongation requires a complex interplay between positive transcription elongation factor b (P-TEFb) and negative transcription elongation factors, DSIF and NELF. DSIF and NELF act as negative transcription elongation factors by increasing the time the polymerase spends at pause sites. DSIF/NELF inhibition of transcription is prevented by P-TEFb in cooperation with FACT. NELF-A is also known as WHSC2 (Wolf-Hirschhorn syndrome candidate 2). Wolf-Hirschhorn syndrome is a multiple malformation syndrome characterized by mental and developmental defects resulting from a hemizygous deletion of the distal short arm of chromosome 4 (4p16.3). The human NELF-A gene maps to chromosome 4p16.3 and encodes a 528 amino acid protein that is expressed in endothelial cells.
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