Product Detail
Product NameNKX3A Antibody
Clone No.C3-H4
Host SpeciesMouse
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, FC
Species ReactivityHu
Immunogen DescRecombinant protein
ConjugateUnconjugated
Other NamesBAPX 2 antibody
BAPX2 antibody
Homeobox protein NK-3 homolog A antibody
Homeobox protein Nkx 3.1 antibody
Homeobox protein Nkx-3.1 antibody
Homeobox protein Nkx3.1 antibody
NK homeobox (Drosophila) family 3 A antibody
NK homeobox family 3 A antibody
NK homeobox, family 3, member A antibody
NK3 homeobox 1 antibody
NK3 transcription factor homolog A antibody
NK3 transcription factor related locus 1 antibody
NKX 3 antibody
Nkx 3.1 antibody
NKX 3A antibody
NKX3 1 antibody
NKX3 antibody
Nkx3-1 antibody
NKX3.1 antibody
Nkx3.1, mouse, homolog of antibody
NKX31_HUMAN antibody
NKX3A antibody
Accession NoSwiss-Prot#:Q99801
Uniprot
Q99801
Gene ID
4824;
Calculated MW26 kDa
Formulation1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
FC: 1:100-1:200
The homeobox gene Nkx-3.1 is the human homolog of Drosophila bagpipe, which, in conjunction with tinman, determines cell fate in the dorsal mesoderm. In mammalian species, Nkx-3.1 is predominantly expressed in prostate, and it regulates prostate development in response to sonic hedgehog (Shh) signaling by exerting growth-suppressive and differentiating effects on prostatic epithelium. Nkx-3.1 is also expressed at lower levels in other tissues, including the heart and gut, in a Shh independent manner, where it plays a role in regulating proliferation of glandular epithelium and in the formation of ducts in prostate and minor salivary glands. Nkx-3.1 preferentially binds the TAAGTA sequence, which has not been reported for any other NK class homeoprotein. The human Nkx-3.1 gene is located on chromosome 8q21, which frequently undergoes a loss of heterozygosity, and although Nkx-3.1 is not a tumor suppressor gene, it may be a useful marker for benign and malignant prostate epithelium.
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