Product Detail
Product NameMERTK Rabbit mAb
Clone No.SR4517
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB;IHC;IP;FC;IF
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Namesc MER antibody c mer proto oncogene tyrosine kinase antibody c-mer antibody cMER antibody cmer protooncogene tyrosine kinase antibody Eyk antibody MER antibody MER receptor tyrosine kinase antibody MERK antibody MERPEN antibody Mertk antibody MERTK c-mer proto-oncogene tyrosine kinase antibody MERTK_HUMAN antibody MGC133349 antibody nmf12 antibody Nyk antibody Proto oncogene tyrosine protein kinase MER antibody Proto oncogene tyrosine protein kinase MER precursor antibody Proto-oncogene c-Mer antibody Receptor tyrosine kinase MerTK antibody RP38 antibody STK kinase antibody Tyrosine-protein kinase Mer antibody
Accession NoSwiss-Prot#:Q12866
Uniprot
Q12866
Gene ID
10461;
Calculated MW188 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
Western blot analysis of MERTK on 293 cell lysates using anti-MERTK antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-MERTK antibody. Counter stained with hematoxylin.
MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulin-like C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2 (PI-PLC 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
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