Welcome to Sabbiotech!     
Email:info@signalwayantibody.com
Welcome Login Register My Cart(0,$0.00)
Location： Home > Recombinant Rabbit Monoclonal Antibodies > M6PR Rabbit mAb

M6PR Rabbit mAb#48669

Datasheet PDF
Availability： Yes
Total Amount:$
ADD TO CART
Detail Pictures Description Publish(0) Other
Product Detail

Product NameM6PR Rabbit mAb

Clone No.SR45-09

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, IP, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other Names300 kDa mannose 6 phosphate receptor antibody
300 kDa mannose 6-phosphate receptor antibody
Cation independent mannose 6 phosphate receptor antibody
Cation-independent mannose-6-phosphate receptor antibody
CD222 antibody
CD222 antigen antibody
CI Man 6 P receptor antibody
CI Man-6-P receptor antibody
CI MPR antibody
CI-M6PR antibody
CI-MPR antibody
CIMPR antibody
IGF 2 receptor antibody
IGF 2R antibody
IGF II receptor antibody
IGF-II receptor antibody
IGF2 receptor antibody
Igf2r antibody
Insulin like growth factor 2 receptor antibody
Insulin like growth factor II receptor antibody
Insulin-like growth factor 2 receptor antibody
Insulin-like growth factor II receptor antibody
M6P R antibody
M6P/IGF2 receptor antibody
M6P/IGF2R antibody
M6PR antibody
mannose 6 phosphate receptor antibody
mannose 6 phosphate receptor, cation independent antibody
MPR 300 antibody
MPR300 antibody
MPRI antibody
MPRI_HUMAN antibody

Accession NoSwiss-Prot#:P11717

Uniprot P11717

Gene ID 3482;

Calculated MW274 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:10,000
IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:50-1:100
Western blot analysis of M6PR on different cell lysates using anti-M6PR antibody at 1/1,000 dilution. Positive control:
Lane 1: HepG2
Lane 2: SW480
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-M6PR antibody. Counter stained with hematoxylin.
ICC staining M6PR in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining M6PR in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining M6PR in HepG2 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of Hela cells with M6PR antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.

If you have published an article using product 48669, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

QUICK NAV

New Products

Cell Signal Transduction

Cancer

Stem Cell

Neuroscience

Help and Support

Contact Us

Terms

Privacy Policy

support

Distributors