Product Detail
Product NameERG Rabbit mAb
Clone No.SP06-04
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, ICC/IF, IHC, CHIP
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAvian erythroblastosis virus E-26 (v-ets) oncogene related antibody
D030036I24Rik antibody
Erg 3 antibody
Erg antibody
ERG/EWS fusion gene, included antibody
ERG/FUS fusion gene, included antibody
ERG/TMPSSR2 fusion gene, included antibody
ERG_HUMAN antibody
ERG1, included antibody
ERG2, included antibody
ets related antibody
ETS-related gene antibody
KCNH2 antibody
Oncogene ERG antibody
p55 antibody
TMPRSS2/ERG fusion antibody
transcriptional regulator ERG (transforming protein ERG) antibody
Transcriptional regulator ERG antibody
Transforming protein ERG antibody
v ets avian erythroblastosis virus E26 oncogene antibody
v ets avian erythroblastosis virus E26 oncogene related antibody
v ets erythroblastosis virus E26 oncogene homolog antibody
v ets erythroblastosis virus E26 oncogene like antibody
v ets erythroblastosis virus E26 oncogene like isoform 2 antibody
v-ets erythroblastosis virus E26 oncogene antibody
v-ets erythroblastosis virus E26 oncogene homolog (avian) antibody
V-ets erythroblastosis virus E26 oncogene like (Avian), isoform CRA_e antibody
Accession NoSwiss-Prot#:P11308
Uniprot
P11308
Gene ID
2078;
Calculated MW55 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Western blot analysis of ERG on Jurkat cell lysates using anti-ERG antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ERG antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-ERG antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-ERG antibody. Counter stained with hematoxylin.
ICC staining ERG in CRC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining ERG in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. This family of genes currently includes Ets-1, Ets-2, Erg-1C3, Elk-1, Elf-1, Elf-5, NERF, PU.1, PEA3, ERM, FEV, ER8l, Fli-1, TEL, Spi-B, ESE-1, ESE-3A, Net, ABT1 and ERF. Members of the Ets gene family exhibit varied patterns of tissue expression, and share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. This conserved domain is essential for Ets-1 binding to DNA and is likely to be responsible for the DNA binding activity of all members of the Ets gene family. Several of these proteins have been shown to recognize similar motifs in DNA that share a centrally located 5'-GGAA-3' element. Erg genes encode for multiple proteins due to alternative splicing and alternative usage of initiation codons.
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