Product Detail
Product NameOlig2 Rabbit mAb
Clone No.SP07-02
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesBasic domain helix loop helix protein class B 1 antibody Basic helix loop helix protein class B 1 antibody BHLHB antibody bHLHB1 antibody bHLHe19 antibody Class B basic helix loop helix protein 1 antibody Class B basic helix-loop-helix protein 1 antibody class E basic helix loop helix protein 19 antibody Class E basic helix-loop-helix protein 19 antibody Human protein kinase C binding protein RACK17 antibody Olig2 antibody OLIG2_HUMAN antibody Oligo2 antibody Oligodendrocyte lineage transcription factor 2 antibody Oligodendrocyte specific bHLH transcription factor 2 antibody Oligodendrocyte transcription factor 2 antibody OTTHUMP00000067569 antibody OTTHUMP00000067570 antibody PRKCBP2 antibody Protein kinase C binding protein 2 antibody Protein kinase C binding protein RACK17 antibody Protein kinase C-binding protein 2 antibody Protein kinase C-binding protein RACK17 antibody RACK17 antibody
Accession NoSwiss-Prot#:Q13516
Uniprot
Q13516
Gene ID
10215;
Calculated MW32 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-Olig2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Olig2 antibody. Counter stained with hematoxylin.
The oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors include OLIG1-OLIG3, which differ in tissue expression. OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas. Therefore, OLIG proteins are candidates for molecular markers of human glial brain tumors, which are the most common primary malignancies of the human brain.
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