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Location： Home > Recombinant Rabbit Monoclonal Antibodies > PDGF Receptor beta Rabbit mAb

PDGF Receptor beta Rabbit mAb#48722

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Product Detail

Product NamePDGF Receptor beta Rabbit mAb

Clone No.SY10-08

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IHC, IP

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesBeta platelet derived growth factor receptor antibody
Beta-type platelet-derived growth factor receptor antibody
CD 140B antibody
CD140 antigen-like family member B antibody
CD140b antibody
CD140b antigen antibody
IBGC4 antibody
IMF1 antibody
JTK12 antibody
OTTHUMP00000160528 antibody
PDGF R beta antibody
PDGF-R-beta antibody
PDGFR 1 antibody
PDGFR antibody
PDGFR beta antibody
PDGFR1 antibody
PDGFRB antibody
PGFRB_HUMAN antibody
Platelet derived growth factor receptor 1 antibody
Platelet derived growth factor receptor beta antibody
Platelet derived growth factor receptor beta polypeptide antibody

Accession NoSwiss-Prot#:P09619

Uniprot P09619

Gene ID 5159;

Calculated MW170 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-5,000
IHC: 1:50-1:200


Western blot analysis of PDGF Receptor beta on NIH/3T3 cell lysates using anti-PDGF Receptor beta antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-PDGF Receptor beta antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-PDGF Receptor beta antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti-PDGF Receptor beta antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-PDGF Receptor beta antibody. Counter stained with hematoxylin.
Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-α and Cβ, which are endowed with protein tyrosine kinase domains. PDGFR-α can bind to both A and B subunits of PDGF, while PDGFR-β can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two α receptors, PDGF-AB induces dimerization of αα and αβ and PDGF-BB induces the formation of three types of dimers, αα, αβ and ββ. Translocation of the PDGFR- gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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