Product Detail
Product NameSHIP Rabbit mAb
Clone No.SY11-08
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, IP, FC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesInositol polyphosphate 5 phosphatase of 145kDa antibody 4 antibody 5-trisphosphate 5-phosphatase 1 antibody hp51CN antibody Inositol polyphosphate 5 phosphatase 145kDa antibody Inositol polyphosphate 5 phosphatase antibody Inositol polyphosphate-5-phosphatase of 145 kDa antibody INPP5D antibody MGC104855 antibody MGC142140 antibody MGC142142 antibody p150Ship antibody Phosphatidylinositol 3,4,5 trisphosphate 5 phosphatase 1 antibody Phosphatidylinositol-3 antibody SH2 containing inositol phosphatase isoform b antibody SH2 domain containing inositol 5' phosphatase 1 antibody SH2 domain containing inositol phosphatase 1 antibody SH2 domain-containing inositol phosphatase 1 antibody SH2 domain-containing inositol-5''-phosphatase 1 antibody SHIP-1 antibody SHIP1 antibody SHIP1_HUMAN antibody Signaling inositol polyphosphate 5 phosphatase SIP 145 antibody SIP-145 antibody SIP145 antibody
Accession NoSwiss-Prot#:Q92835
Uniprot
Q92835
Gene ID
3635;
Calculated MW133/109 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
FC: 1:50-1:100
Western blot analysis of SHIP on different lysates using anti-SHIP antibody at 1/1,000 dilution. Positive control: Lane 1: Daudi Lane 2: THP-1
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-SHIP antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-SHIP antibody. Counter stained with hematoxylin.
Flow cytometric analysis of Raji cells with SHIP antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
The major translational product of the v-Fms oncogene, originally isolated from the McDonough strain of feline sarcoma virus, has been identified as a glycoprotein with intrinsic tyrosine kinase activity. The v-Fms human cellular homolog, c-Fms, has been molecularly cloned and mapped to band q34 on chromosome 5, and identified as the receptor for hematopoietic ligand, CSF-1. Ligand-induced activation of the intrinsic CSF-1R protein tyrosine kinase triggers its interaction with cytoplasmic effector molecules. One such effector molecule, SHIP-1 p145 (SH2-containing-inositol phosphatase), associates with activated Fms. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.
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