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Location： Home > Recombinant Rabbit Monoclonal Antibodies > Calponin Rabbit mAb

Calponin Rabbit mAb#48742

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Product Detail

Product NameCalponin Rabbit mAb

Clone No.SI67-01

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC

Species ReactivityHu, Ms, Rt, Dog, Pig

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesBasic calponin antibody
Calponin 1 antibody
Calponin 1 basic smooth muscle antibody
Calponin H1 antibody
Calponin H1 smooth muscle antibody
Calponin-1 antibody
Calponin1 antibody
Calponins basic antibody
CNN 1 antibody
Cnn1 antibody
CNN1_HUMAN antibody
Epididymis secretory protein Li 14 antibody
HEL S 14 antibody
Sm Calp antibody
SMCC antibody
smooth muscle antibody

Accession NoSwiss-Prot#:P51911

Uniprot P51911

Gene ID 1264;

Calculated MW33 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200

Western blot analysis of Calponin on Hela cell lysates using anti-Calponin antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-Calponin antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse bladder tissue using anti-Calponin antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti-Calponin antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-Calponin antibody. Counter stained with hematoxylin.
ICC staining Calponin in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Calponin regulates smooth muscle cell contraction and is a marker of smooth muscle cell differentiation. Calponin, an Actin- and Tropomyosin-binding protein, is characterized as an inhibitory factor of smooth-muscle actomyosin activity. Calponin is implicated in the regulation of smooth muscle contraction through its interaction with F-Actin and inhibition of the Actin-activated MgATPase activity of phosphorylated Myosin. Both properties are lost following phosphorylation (primarily at Serine 175) by protein kinase C or calmodulin-dependent protein kinase II. The three forms of Calponin, Calponin 1 (basic Calponin), Calponin 2 (neutral Calponin) and Calponin 3 (acidic Calponin), are found in smooth muscle tissue. Additionally, Calponin 2 is found in heart muscle tissue and Calponin 3 is found in the brain.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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