Product Detail
Product NameCD11c Rabbit mAb
Clone No.SI19-06
Host SpeciesRecombinant Rabbit
ClonalityMonoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, IP
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other Names95 alpha chain antibody 95 antibody CD 11c antibody CD11 antigen-like family member C antibody CD11c antibody CD11c antigen antibody Complement component 3 receptor 4 subunit antibody CR4 antibody Integrin alpha X antibody Integrin alpha X chain antibody Integrin alpha-X antibody Integrin aX antibody Integrin subunit alpha X antibody integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody integrin, alpha X (complement component 3 receptor 4 subunit antibody ITAX_HUMAN antibody ITGAX antibody LEU M5 alpha subunit antibody Leu M5 antibody Leukocyte adhesion glycoprotein p150 95 alpha chain antibody Leukocyte adhesion glycoprotein p150 antibody Leukocyte adhesion receptor p150 95 antibody Leukocyte adhesion receptor p150 antibody Leukocyte surface antigen p150 95 alpha subunit antibody Leukocyte surface antigen p150 alpha subunit antibody Myeloid membrane antigen alpha subunit antibody p150 95 integrin alpha chain antibody p150 antibody p150/95 antibody SLEB6 antibody
Accession NoSwiss-Prot#:P20702
Uniprot
P20702
Gene ID
3687;
Calculated MW128 kDa(Predicted)
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CD11c antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD11c antibody. Counter stained with hematoxylin.
Integrin αX (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with β2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin αX/β2 shares similar properties of the αM/β2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin αX is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin αX include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin αX is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.
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