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Location： Home > Recombinant Rabbit Monoclonal Antibodies > STAT1 Rabbit mAb

STAT1 Rabbit mAb#48752

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Product Detail

Product NameSTAT1 Rabbit mAb

Clone No.SJ01-89

ClonalityMonoclonal

PurificationProA affinity purified

ApplicationsWB, IP, FC

Species ReactivityHu, Ms

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesSignal transducer and activator of transcription 1 91kD antibody
CANDF7 antibody
DKFZp686B04100 antibody
IMD31A antibody
IMD31B antibody
IMD31C antibody
ISGF 3 antibody
ISGF-3 antibody
OTTHUMP00000163552 antibody
OTTHUMP00000165046 antibody
OTTHUMP00000165047 antibody
OTTHUMP00000205845 antibody
Signal transducer and activator of transcription 1 91kDa antibody
Signal transducer and activator of transcription 1 antibody
Signal transducer and activator of transcription 1, 91kD antibody
Signal transducer and activator of transcription 1-alpha/beta antibody
STAT 1 antibody
Stat1 antibody
STAT1_HUMAN antibody
STAT91 antibody
Transcription factor ISGF 3 components p91 p84 antibody
Transcription factor ISGF-3 components p91/p84 antibody

Accession NoSwiss-Prot#:P42224

Uniprot P42224

Gene ID 6772;

Calculated MW83/87 kDa

FormulationRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20˚C

Application Details

WB: 1:1,000-1:2,000



FC: 1:50-1:100

Flow cytometric analysis of MCF-7 cells with STAT1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
All lanes use the Antibody at 1:3K dilution for 1 hour at room temperature.
All lanes use the Antibody at 1:3K dilution for 1 hour at room temperature.

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

If you have published an article using product 48752, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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