Product Detail
Product NamePD1 Rabbit mAb
Clone No.SJ01-91
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCD279 antibody
CD279 antigen antibody
hPD 1 antibody
hPD l antibody
hPD-1 antibody
hSLE1 antibody
PD 1 antibody
PD-1 antibody
PD1 antibody
PDCD 1 antibody
PDCD1 antibody
PDCD1_HUMAN antibody
Programmed cell death 1 antibody
Programmed cell death 1 protein antibody
Programmed cell death protein 1 antibody
Protein PD 1 antibody
Protein PD-1 antibody
SLEB2 antibody
Systemic lupus erythematosus susceptibility 2 antibody
Accession NoSwiss-Prot#:Q15116
Uniprot
Q15116
Gene ID
5133;
Calculated MW32 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
Western blot analysis of over-expressed PD1(whole extracellular domain) on 293T cell lysate using anti-PD1 antibody at 1/500 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-PD1 antibody. Counter stained with hematoxylin.
Pdcd-1 (Programmed Cell Death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. Pdcd-1 contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) within the cytoplasmic domain, which is conserved between the mouse and human homologs. Expression of Pdcd-1 is detected in mouse thymus, and it is induced in stimulated B and T cell lines, where it may play a role in the negative regulation of various immune responses. Receptors such as Pdcd-1 function by recruiting tyrosine phosphatases, including SHP-1 and SHIP, which are responsible for altering various B cell responses. Additionally, in activated lymphocytes, Pdcd-1 mediates the activation of the classical type of programmed cell death.
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