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Location： Home > Recombinant Rabbit Monoclonal Antibodies > PTEN Rabbit mAb

PTEN Rabbit mAb#48756

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Product Detail

Product NamePTEN Rabbit mAb

Clone No.SJ19-03

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other Names10q23del antibody
BZS antibody
DEC antibody
GLM2 antibody
MGC11227 antibody
MHAM antibody
MMAC1 antibody
MMAC1 phosphatase and tensin homolog deleted on chromosome 10 antibody
Mutated in multiple advanced cancers 1 antibody
Phosphatase and tensin homolog antibody
Phosphatase and tensin like protein antibody
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN antibody
Pten antibody
PTEN_HUMAN antibody
PTEN1 antibody
TEP1 antibody

Accession NoSwiss-Prot#:P60484

Uniprot P60484

Gene ID 5728;

Calculated MW54 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-5,000
IHC: 1:50-1:200
ICC: 1:100-1:500

Western blot analysis of PTEN on different lysates using anti-PTEN antibody at 1/1,000 dilution. Positive control:
Lane 1: MCF-7
Lane 2: Hela
Lane 3: 293T
Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-PTEN antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-PTEN antibody. Counter stained with hematoxylin.
ICC staining PTEN in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining PTEN in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining PTEN in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm and shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.

If you have published an article using product 48756, please notify us so that we can cite your literature.

et al,Effect of Fushengong Decoction on PTEN/PI3K/AKT/NF-KB Pathway in Rats With Chronic Renal Failure via Dual-Dimension Network Pharmacology Strategy.In Front Pharmacol on 2022 Mar 15 by Hongyu Luo, Munan Wang,et al..PMID: 35370667 , (2022),
PMID: 35370667
et al,Effect of Fushengong Decoction on PTEN/PI3K/AKT/NF-κB Pathway in Rats With Chronic Renal Failure via Dual-Dimension Network Pharmacology Strategy. In Front Pharmacol on 2022 Mar 15 by Hongyu Luo, Munan Wang, et al..PMID: 35370667 , (2022),
PMID: 35370667

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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