Product Detail
Product NameCaveolin-3 Rabbit mAb
Clone No.SY22-06
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesCAV3 antibody CAV3_HUMAN antibody Caveolin 3 antibody Caveolin-3 antibody LGMD1C antibody LQT9 antibody M-caveolin antibody MGC126100 antibody MGC126101 antibody MGC126129 antibody OTTHUMP00000115603 antibody OTTHUMP00000207105 antibody VIP 21 antibody VIP21 antibody
Accession NoSwiss-Prot#:P56539
Uniprot
P56539
Gene ID
859;
Calculated MW17 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-5,000
Western blot analysis of Caveolin-3 on different lysates using anti-Caveolin-3 antibody at 1/1,000 dilution. Positive control: Lane 1: Mouse heart Lane 2: Mouse skeletal muscle
Caveolae (also known as plasmalemmal vesicles) are 50-100 nM flask-shaped membranes that represent a subcompartment of the plasma membrane. On the basis of morphological studies, caveolae have been implicated to function in the transcytosis of various macromolecules (including LDL) across capillary endothelial cells, uptake of small molecules via potocytosis and the compartmentalization of certain signaling molecules including G protein-coupled receptors. Three proteins, caveolin-1, caveolin-2 and caveolin-3, have been identified as principal components of caveolae. Two forms of caveolin-1, designated alpha and beta, share a distinct but overlapping cellular distribution and differ by an amino terminal 31 amino acid sequence which is absent from the beta isoform. Caveolin-1 shares 31% identity with caveolin-2 and 65% identity with caveolin-3 at the amino acid level. Functionally, the three proteins differ in their interactions with heterotrimeric G protein isoforms.
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