Product Detail
Product NameTCF3 Rabbit mAb
Clone No.SY0258
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, FC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAGM8 antibody bHLHb21 antibody Class B basic helix-loop-helix protein 21 antibody E12 antibody E2A antibody E2A immunoglobulin enhancer binding factors E12/E47 antibody E47 antibody Helix loop helix protein HE47 antibody Immunoglobulin enhancer-binding factor E12/E47 antibody Immunoglobulin transcription factor 1 antibody ITF1 antibody Kappa-E2-binding factor antibody MGC129647 antibody MGC129648 antibody Negative vitamin D response element binding protein antibody NOL1-TCF3 fusion antibody TCF-3 antibody Tcf3 antibody TFE2_HUMAN antibody transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) antibody Transcription factor 3 antibody transcription factor 3 variant 3 antibody Transcription factor E2-alpha antibody Transcription factor ITF-1 antibody VDIR antibody VDR interacting repressor antibody vitamin D receptor-interacting repressor antibody
Accession NoSwiss-Prot#:P15923
Uniprot
P15923
Gene ID
6929;
Calculated MW67 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
FC: 1:50-1:100
Flow cytometric analysis of 293 cells with TCF3 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development include Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes. Both homo- and heterooligomers of these proteins are able to distinguish very closely related E box proteins and are believed to play important roles in lineage specific gene expression.
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