Product Detail
Product NamePI 3 Kinase Class 3 Rabbit mAb
Clone No.SY0286
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NameshVps34 antibody MGC61518 antibody Phosphatidylinositol 3 kinase catalytic subunit type 3 antibody Phosphatidylinositol 3 kinase class 3 antibody Phosphatidylinositol 3 kinase p100 subunit antibody Phosphatidylinositol 3-kinase catalytic subunit type 3 antibody Phosphatidylinositol 3-kinase p100 subunit antibody Phosphoinositide 3 kinase class 3 antibody Phosphoinositide-3-kinase class 3 antibody PI3 kinase type 3 antibody PI3-kinase type 3 antibody PI3K type 3 antibody Pik3c3 antibody PK3C3_HUMAN antibody PtdIns 3 kinase type 3 antibody PtdIns-3-kinase type 3 antibody Vps 34 antibody Vps34 antibody
Accession NoSwiss-Prot#:Q8NEB9
Uniprot
Q8NEB9
Gene ID
5289;
Calculated MW100 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
IHC: 1:50-1:200
Western blot analysis of PI 3 Kinase Class 3 on C2C12 cells lysates using anti-PI 3 Kinase Class 3 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-PI 3 Kinase Class 3 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human gastric carcinoma tissue using anti-PI 3 Kinase Class 3 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-PI 3 Kinase Class 3 antibody. Counter stained with hematoxylin.
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the 3' OH position of the inositol ring of inositol lipids. PI 3-kinase p100 (phosphoinositide-3-kinase p100 subunit), also known as hVps34 or PIK3C3 (phosphoinositide-3-kinase, class III), is a member of the PI3/PI4-kinase family. It is ubiquitously expressed with predominant expression in skeletal muscle and is believed to participate in endosome to lysosome transport, multivesicular body formation, autophagy and retrograde endosome to Golgi transport. PI 3-kinase p100 is the catalytic subunit of class III PI3Ks and forms a heterodimer with p150, a regulatory subunit of class 3 PI3Ks. PI 3-kinase p100 exclusively phosphorylates phosphatidylinositol to produce PtdIns3P. Unlike class I PI3Ks, whose activities are enhanced in the presence of magnesium, PI 3-kinase p100 activity is enhanced by manganese. Its activity can also be regulated by nutrients, suggesting an important role of PI-3 kinase p100 in the regulation of mTOR protein synthesis and autophagy.
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