Product Detail
Product NameLGR5/GPR49 Rabbit mAb
Clone No.SU32-04
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP, FC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesFEX antibody
G protein coupled receptor 49 antibody
G protein coupled receptor 67 antibody
g protein-coupled receptor fex antibody
G-protein coupled receptor 49 antibody
G-protein coupled receptor 67 antibody
G-protein coupled receptor HG38 antibody
GPR 49 antibody
GPR 67 antibody
GPR49 antibody
GPR67 antibody
GRP 49 antibody
GRP49 antibody
HG 38 antibody
HG38 antibody
Leucine rich repeat containing G protein coupled receptor 5 antibody
Leucine-rich repeat-containing G-protein coupled receptor 5 antibody
LGR 5 antibody
LGR5 antibody
LGR5_HUMAN antibody
MGC117008 antibody
Orphan G protein coupled receptor HG38 antibody
Accession NoSwiss-Prot#:O75473
Uniprot
O75473
Gene ID
8549;
Calculated MW100 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000
FC: 1:50-1:100
Western blot analysis of LGR5/GPR49 on SH-SY-5Y lysates using anti-LGR5/GPR49 antibody at 1/1,000 dilution.
Flow cytometric analysis of SH-SY-5Y cells with LGR5/GPR49 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors or heptahelical receptors, interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers, such as diacylglycerol, cyclic AMP, inositol phosphates and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. LGR5 (leucine-rich repeat-containing G-protein coupled receptor 5), also known as GPR49 or GPR67, is a 907 amino acid multi-pass membrane protein that contains 17 leucine-rich repeats and belongs to the G protein-coupled receptor family. Expressed in placenta, skeletal muscle and spinal cord, LGR5 functions as an orphan receptor that is thought to play an important role in embryonic growth control and cellular differentiation. Overexpression of LGR5 is associated with increased tumor susceptibility and malignant transformation, implicating LGR5 as a potent tumor-inducing protein.
If you have published an article using product 48810, please notify us so that we can cite your literature.
Yes
