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Caspase-1 Rabbit mAb#48847

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Product Detail

Product NameCaspase-1 Rabbit mAb

Clone No.SU40-07

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, IHC, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesCASP-1 antibody
CASP1 antibody
CASP1_HUMAN antibody
Caspase 1 antibody
Caspase-1 subunit p10 antibody
ICE antibody
IL-1 beta-converting enzyme antibody
IL-1BC antibody
IL1 beta converting enzyme antibody
IL1B convertase antibody
Interleukin 1 beta convertase antibody
Interleukin 1B converting enzyme antibody
Interleukin-1 beta convertase antibody
Interleukin-1 beta-converting enzyme antibody
p45 antibody

Accession NoSwiss-Prot#:P29466

Uniprot P29466

Gene ID 834;

Calculated MW45 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200


FC: 1:50-1:100
Western blot analysis of Caspase-1 on different lysates using anti-Caspase-1 antibody at 1/1,000 dilution.

Positive control:

Lane 1: THP-1

Lane 2: Jurkat

Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-Caspase-1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Caspase-1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-Caspase-1 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of Hela cells with Caspase-1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Caspase-1 promotes maturation of interleukin IL-1β and interleukin18 (IL-18) by proteolytic cleavage of precursor forms into biologically active pro-inflamatory cytokines. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. The highly conserved family of caspases mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins and propagation of other pro-apoptotic molecules. The human Caspase-1 gene maps to chromosome 2q14 and encodes a cytoplasmic protein expressed in liver, heart, skeletal muscle kidney and testis. Caspase-1 has been implicated in inflammation, septic shock, and other situations such as wound healing and the growth of certain leukemias.

If you have published an article using product 48847, please notify us so that we can cite your literature.

et al,Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor 伪-mediated autophagy. In J Adv Res on 2020 Aug 24 by Qinghai Meng, Yu Li,et al..PMID:33364052 , (2021),
PMID: 33364052

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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