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Location： Home > Recombinant Rabbit Monoclonal Antibodies > PRMT5 Rabbit mAb

PRMT5 Rabbit mAb#48880

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Product Detail

Product NamePRMT5 Rabbit mAb

Clone No.ST51-06

Host SpeciesRecombinant Rabbit

Clonality Monoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other Names72 kDa ICln binding protein antibody
72 kDa ICln-binding protein antibody
ANM5_HUMAN antibody
Histone synthetic lethal 7, S. cerevisiae, homolog of antibody
Histone-arginine N-methyltransferase PRMT5 antibody
HMT1 hnRNP methyltransferase like 5 antibody
HOMOLOG OF; SKB1 antibody
HRMT1L5 antibody
IBP72 antibody
Jak-binding protein 1 antibody
JBP 1 antibody
JBP1 antibody
PRMT 5 antibody
PRMT5 antibody
Protein arginine methyltransferase 5 antibody
Protein arginine N methyltransferase 5 antibody
Protein arginine N methyltransferase 5 N terminally processed antibody
Protein arginine N-methyltransferase 5 antibody
S. POMBE antibody
S. POMBE HOMOLOG OF; SKB1 antibody
SHK1 KINASE BINDING PROTEIN 1 antibody
Shk1 kinase binding protein 1 homolog antibody
Shk1 kinase-binding protein 1 homolog antibody
Shk1 kinase/binding protein 1, S. pombe, homolog of antibody
SKB 1 antibody
SKB1 antibody
SKB1 homolog antibody
SKB1: SKB1 homolog (S. pombe) antibody
SKB1Hs antibody

Accession NoSwiss-Prot#:O14744

Uniprot O14744

Gene ID 10419;

Calculated MW73 kDa

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200

Western blot analysis of PRMT5 on A431 cell lysates using anti-PRMT5 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-PRMT5 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PRMT5 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse liver tissue using anti-PRMT5 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-PRMT5 antibody. Counter stained with hematoxylin.
ICC staining PRMT5 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of a motor neuron (SMN) protein and is enhanced by modification of specific Arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalyzed by the methylosome, a complex comprised of the type II methyltransferase PRMT5, also designated JAK-binding protein 1), (JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their Arginine- and Glycine-rich (RG) domains, while pICln binds the Sm domains. PRMT5 is a distinct member of the protein-Arginine methyltransferase (PRMT) family, and predominantly localizes to the cytoplasm in a wide variety of tissues. PRMT5 also associates specifically with the transcription start site region of the cyclin E1 promoter, and, therefore, is involved in the control of transcription and proliferation. The gene encoding human PRMT5 maps to chromosome 14q11.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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