Product Detail
Product NameCytokeratin 15 Rabbit mAb
Clone No.ST04-85
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, FC
Species ReactivityHu, Ms
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesAI528832 antibody CK 15 antibody CK-15 antibody CK15 antibody Cytokeratin-15 antibody Cytokeratin15 antibody K15 antibody K1C15_HUMAN antibody K1CO antibody Ka15 antibody Keratin 15 antibody Keratin 15 basic antibody Keratin 15 beta antibody Keratin antibody Keratin complex 1 acidic gene 15 antibody Keratin type I cytoskeletal 15 antibody Keratin-15 antibody Keratin15 antibody KRT 15 antibody Krt1-15 antibody KRT15 antibody KRTB antibody KRTL15 antibody Type I cytoskeletal 15 antibody Type I keratin Ka15 antibody
Accession NoSwiss-Prot#:P19012
Uniprot
P19012
Gene ID
3866;
Calculated MW45 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
IHC:1:50-1:200
FC: 1:50-1:100
Western blot analysis of Cytokeratin 15 on A431 cell lysates using anti-Cytokeratin 15 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-Cytokeratin 15 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue using anti-Cytokeratin 15 antibody. Counter stained with hematoxylin.
Cytokeratin 15 (CK15, K15, K1CO, keratin15, type I cytoskeletal 15) is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains, and are clustered in a region on chromosome 17q21.2. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
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