Product Detail
Product NameHIF-1 beta Rabbit mAb
Clone No.ST05-25
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC
Species ReactivityHu
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesarnT antibody ARNT protein antibody ARNT_HUMAN antibody Aryl hydrocarbon receptor nuclear translocator antibody bHLHe2 antibody Class E basic helix-loop-helix protein 2 antibody Dioxin receptor antibody Dioxin receptor nuclear translocator antibody Drnt antibody HIF 1 beta antibody HIF 1beta antibody HIF-1-beta antibody HIF1-beta antibody HIF1B antibody HIF1beta antibody Hypoxia Inducible Factor 1 antibody Hypoxia inducible factor 1 beta antibody Hypoxia-inducible factor 1-beta antibody nuclear translocator antibody Tango antibody
Accession NoSwiss-Prot#:P27540
Uniprot
P27540
Gene ID
405;
Calculated MW87 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
Western blot analysis of HIF-1 beta on human liver lysates using anti-HIF-1 beta antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-HIF-1 beta antibody. Counter stained with hematoxylin.
AhR, Arnt 1, Arnt 2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common PAS motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. Arnt 2 (aryl hydrocarbon receptor nuclear translocator 2), also known as Hif-2b or bHLHe1, is a 712 amino acid nuclear protein that is exclusively expressed in adult brain and kidney. Containing a basic helix-loop-helix (bHLH) domain, a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains, Arnt 2 specifically recognizes the xenobiotic response element (XRE).
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