Product Detail
Product NameEstrogen Related Receptor alpha Rabbit mAb
Clone No.SC57-07
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IP, FC
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesErr 1 antibody
ERR a antibody
ERR alpha antibody
ERR-alpha antibody
Err1 antibody
ERR1 protein antibody
ERR1_HUMAN antibody
ERRa antibody
ERRalpha antibody
ESRL 1 antibody
ESRL1 antibody
ESRR A antibody
Esrra antibody
Estrogen receptor like 1 antibody
Estrogen receptor related 1 antibody
estrogen receptor related receptor alpha antibody
Estrogen receptor-like 1 antibody
Estrogen related receptor alpha antibody
Estrogen-related receptor alpha antibody
Estrra antibody
hERR1 antibody
NR3B1 antibody
Nuclear receptor subfamily 3 group B member 1 antibody
Steroid hormone receptor ERR1 antibody
Accession NoSwiss-Prot#:P11474
Uniprot
P11474
Gene ID
2101;
Calculated MW53 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-1:2,000
FC: 1:50-1:100
Western blot analysis of Estrogen Related Receptor alpha on MCF-7 cell lysates using anti-Estrogen Related Receptor alpha antibody at 1/1,000 dilution.
Flow cytometric analysis of Hela cells with Estrogen Related Receptor alpha antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
Estrogen related receptor alpha (ERRα) is a nuclear receptor in the superfamily of ligand-regulated transcription factors and is a member of the NR3B orphan nuclear receptor subgroup (consisting of α, β and γ). ERRα plays a role in modulating the estrogen signaling pathway. In addition, the expression of ERRα has been shown to increase during fasting and cold exposure. ERRα may be important for regulating mitochondrial biogenesis and oxidative metabolism by acting directly on genes necessary for mitochondrial function. Mice lacking ERRα are unable to maintain their body temperature in the cold. ERRα may also be involved in the maintenance and formation of cartilage. This information could be useful in finding therapeutic agents for a variety of diseases affecting the joints.
If you have published an article using product 48925, please notify us so that we can cite your literature.
Yes
