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p63 Rabbit mAb#48958

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Product Detail

Product Namep63 Rabbit mAb

Clone No.SC06-31

ClonalityMonoclonal

PurificationProA affinity purified

ApplicationsWB, ICC/IF, IHC, FC

Species ReactivityHu, Ms, Rt

Immunogen Descrecombinant protein

ConjugateUnconjugated

Other NamesAIS antibody
Amplified in squamous cell carcinoma antibody
B(p51A) antibody
B(p51B) antibody
Chronic ulcerative stomatitis protein antibody
CUSP antibody
DN p63 alpha 1 antibody
DNp63 antibody
EEC3 antibody
id:ibd3516 antibody
Keratinocyte transcription factor antibody
Keratinocyte transcription factor KET antibody
KET antibody
LMS antibody
MGC115972 antibody
MGC192897 antibody
NBP antibody
OFC8 antibody
OTTHUMP00000209732 antibody
OTTHUMP00000209733 antibody
OTTHUMP00000209734 antibody
OTTHUMP00000209735 antibody
OTTHUMP00000209737 antibody
OTTHUMP00000209738 antibody
OTTHUMP00000209739 antibody
OTTHUMP00000209740 antibody
OTTHUMP00000209741 antibody
OTTHUMP00000209742 antibody
OTTHUMP00000209743 antibody
OTTHUMP00000209744 antibody
p40 antibody
p51 antibody
P51/P63 antibody
p53-related protein p63 antibody
p53CP antibody
p63 antibody
P63_HUMAN antibody
p73H antibody
p73L antibody
RHS antibody
SHFM4 antibody
TAp63alpha antibody
TP53CP antibody
TP53L antibody
TP63 antibody
TP73L antibody
Transformation related protein 63 antibody
Transformation-related protein 63 antibody
Trp53rp1 antibody
Trp63 antibody
Tumor protein 63 antibody
Tumor protein p53-competing protein antibody
Tumor protein p53-like antibody
Tumor protein p63 antibody
Tumor protein p63 deltaN isoform delta antibody
Tumor protein p73 antibody
Tumor protein p73-like antibody

Accession NoSwiss-Prot#:Q9H3D4

Uniprot Q9H3D4

Gene ID 8626;

Calculated MW55 kDa

Concentration1.5 mg/ml

Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

StorageStore at -20˚C

Application Details

WB: 1:1,000-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:50-1:100

Western blot analysis of p63 on human kidney lysates using anti-p63 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-p63 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded mouse prostate tissue using anti-p63 antibody. Counter stained with hematoxylin.
ICC staining p63 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of A431 cells with p63 antibody at 1/50 dilution (black) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.

The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. In addition to p53, mammalian cells contain two p53 family members, p63 and p73, which are similar to p53 in both structure and function. While p63 can induce p53-responsive genes and apoptosis, mutation of p63 rarely results in tumors. Research investigators frequently observe amplification of the p63 gene in squamous cell carcinomas of the lung, head and neck. The p63 gene contains an alternative transcription initiation site that yields a 40 kDa δNp63 lacking the transactivation domain, and alternative splicing at the carboxy-terminus yields the α, β, and γ isoforms.

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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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