Product Detail
Product NameMst2 Rabbit mAb
Clone No.SC05-83
Host SpeciesRecombinant Rabbit
Clonality Monoclonal
PurificationProA affinity purified
ApplicationsWB, IHC, IP
Species ReactivityHu, Ms, Rt
Immunogen Descrecombinant protein
ConjugateUnconjugated
Other NamesDKFZp686A2068 antibody FLJ90748 antibody KRS1 antibody KRS2 antibody Mammalian STE20 like protein kinase 1 antibody Mammalian STE20 like protein kinase 2 antibody MST 1 antibody MST 2 antibody MST1 antibody MST2 antibody Serine/threonine kinase 3 (STE20 homolog yeast) antibody Serine/threonine kinase 3 (Ste20 yeast homolog) antibody Serine/threonine kinase 3 antibody Serine/threonine kinase 4 antibody Serine/threonine protein kinase 3 antibody Serine/threonine protein kinase 4 antibody Serine/threonine protein kinase Krs 1 antibody Serine/threonine protein kinase Krs 2 antibody STE20 like kinase MST1 antibody STE20 like kinase MST2 antibody STK 3 antibody STK 4 antibody STK3 antibody STK4 antibody YSK3 antibody
Accession NoSwiss-Prot#:Q13188
Uniprot
Q13188
Gene ID
6788;
Calculated MW36/56 kDa
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
StorageStore at -20˚C
Application Details
WB: 1:1,000-5,000
IHC: 1:50-1:200
Western blot analysis of Mst2 on different lysates using anti-Mst2 antibody at 1/1,000 dilution. Positive control: Lane 1: CRC Lane 2: HCT116
Immunohistochemical analysis of paraffin-embedded mouse placenta tissue using anti-Mst2 antibody. Counter stained with hematoxylin.
Sterile-20 (Ste20) is a serine/threonine kinase in Saccharomyces cerevisiae that is involved in relaying signals from G protein-coupled receptors to cyto-solic MAP kinase cascades. Mammalian protein kinases that display sequence similarity to Ste20 are divided into two groups, the PAK subfamily and the GCK subfamily. The PAK subfamily members contain a C-terminal catalytic domain and an N-terminal regulatory domain with a p21Rac/Cdc42-binding site, and these kinases can activate both p38 MAPK and JNK. The GCK subfamily members contain a C-terminal regulatory domain and an N-terminal catalytic domain, and they have diverse roles in many pathways, including the activation of ERK, JNK, p38 MAPK, and caspase-3. The mammalian Ste20-like kinases (MST kinases), also known as Krs proteins, are members of the GCK subfamily. Ksr-1 (MST-2) and Ksr-2 (MST-1) are both direct substrates of caspase-3 that accelerate caspase-3 activation. MST-3 is ubiquitously expressed in mammalian tissue and can phosphorylate exogenous substrates as well as itself. MST-4 is highly expressed in placenta, thymus, and peripheral blood leukocytes, and it specifically activates ERK.
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